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Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases

[ Vol. 19 , Issue. 9 ]

Author(s):

Athanasios Alexiou*, Bilal Nizami, Faez Iqbal Khan, Georgia Soursou, Charalampos Vairaktarakis, Stylianos Chatzichronis, Vasilis Tsiamis, Vasileios Manztavinos, Nagendra Sastry Yarla and Ghulam Md Ashraf*   Pages 850 - 857 ( 8 )

Abstract:


Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, neurophysiologic and biochemical alterations within the mitochondrial populations can reveal deficits in brain energy metabolism resulting in Mild Cognitive Impairment, abnormal neural development, autonomic dysfunction and other mitochondrial disorders. Additionally, in cases of Alzheimer’s disease or Parkinson’s disease, a significant number of proteins seem to form unordered and problematic structures, leading through unknown mechanisms to pathological conditions. While the proteins structure prediction problem is still an open challenge regarding its complexity, several features associated with the correlations of misfolding proteins and Neurodegeneration are discussed in the present study and a computational analysis for the proteins Amyloid Beta, Tau, α-Synuclein, Parkin, Pink1, MFN1, MFN1, OPA1, and DNM1L is also presented.

Keywords:

Proteins misfolding, mitochondrial dynamics, mitochondrial lesions, neurodegeneration, Alzheimer's disease, Parkinson's disease, Huntington's disease, CMT2A, reactive oxygen species, amyloid beta, tau, α -synuclein, parkin, PINK1, MFN1, MFN2, OPA1, DNM1L.

Affiliation:

Novel Global Community Educational Foundation, Herbersham, School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, Department of Chemistry, Rhodes University, Grahamstown 6139, Novel Global Community Educational Foundation, Herbersham, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35100 Lamia, Novel Global Community Educational Foundation, Herbersham, Novel Global Community Educational Foundation, Herbersham, Novel Global Community Educational Foundation, Herbersham, Novel Global Community Educational Foundation, Herbersham, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589

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