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Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

[ Vol. 19 , Issue. 3 ]

Author(s):

Muhammad Ali Hashmi, Afsar Khan*, Umar Farooq and Sehroon Khan   Pages 292 - 301 ( 10 )

Abstract:


Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.

Keywords:

Anticancer, cyclooxygenase, COX-2, alkaloids, enzyme inhibition, anti-inflammatory, anti-tumor.

Affiliation:

Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 560201, Yunnan

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