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Parvalbumin as a Pleomorphic Protein

[ Vol. 18 , Issue. 8 ]

Author(s):

Eugene A. Permyakov, Vladimir N. Uversky and Sergei E. Permyakov   Pages 780 - 794 ( 15 )

Abstract:


Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functionality. This review sums up these findings and discusses their potential physiological significance.

Keywords:

Parvalbumin, oncomodulin, metal binding, protein unfolding, protein isoforms, structural microheterogeneity, intrinsically disordered protein, antioxidant activity, allergen.

Affiliation:

Institute for Biological Instrumentation of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290, Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, FL, Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow Region 142290

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