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Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury

[ Vol. 18 , Issue. 12 ]

Author(s):

Yue Xu, Song Zeng, Qiang Zhang, Zijian Zhang and Xiaopeng Hu*   Pages 1195 - 1199 ( 5 )

Abstract:


In the past decade, rapid developments in stem cell studies have occurred. Researchers have confirmed the plasticity of bone marrow stem cells and the repair and regeneration effects of bone marrow hematopoietic stem cells on solid organs. These findings have suggested the possibility of using bone marrow stem cell mobilizers to repair and regenerate injured organs. Recent studies on the effects of granulocyte colony-stimulating factor (G-CSF) and Plerixafor (AMD3100) on mouse acute kidney injury models have confirmed that the use of bone marrow stem cell mobilizers may be an effective therapeutic measure. This paper summarizes studies describing the effects of G-CSF and AMD3100 on various acute kidney injury models over the past 10 years.

Keywords:

Acute kidney injuries, granulocyte colony-stimulating factor, plerixafor, bone marrow stem cells.

Affiliation:

Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, NO.8 GongTi South Road, Beijing

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