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ADP-Ribosyltransferases and Poly ADP-Ribosylation

[ Vol. 16 , Issue. 6 ]

Author(s):

Chao Liu and Xiaochun Yu   Pages 491 - 501 ( 11 )

Abstract:


Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD+) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD+ to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

Keywords:

ADP-ribosylation, ADP-ribosyltransferase, ART, ARTD, PAR, PARylation.

Affiliation:

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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