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The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation

[ Vol. 16 , Issue. 4 ]


Pengfei Li, Jin Liu, Junzhong Sun and Haifeng Duan   Pages 295 - 300 ( 6 )


In this study, the culture supernatant of LPS-treated MSCs was collected and served as a conditioned medium (CM). It was found that the LPS-CM promoted the proliferation of tumor cells (SKBR3, MDA-MB-231, A549, 95D and HepG2). In addition, the colony formation ability was also enhanced by LPS-CM incubation. The inflammatory cytokines, IL-6 and IL-8, were demonstrated to be up-regulated in the LPS-CM, which we supposed to function in the tumor-growth promotion in vitro.


Inflammatory cytokine, LPS, MSC, tumor growth.


Department of Hematology and Oncology, The First Affiliated Hospital of General Hospital of Chinese People’s Liberation Army (PLA), No. 52,Fucheng Road, Haidian District, Beijing 100039, China.

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