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The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation

[ Vol. 16 , Issue. 4 ]

Author(s):

Pengfei Li, Jin Liu, Junzhong Sun and Haifeng Duan   Pages 295 - 300 ( 6 )

Abstract:


In this study, the culture supernatant of LPS-treated MSCs was collected and served as a conditioned medium (CM). It was found that the LPS-CM promoted the proliferation of tumor cells (SKBR3, MDA-MB-231, A549, 95D and HepG2). In addition, the colony formation ability was also enhanced by LPS-CM incubation. The inflammatory cytokines, IL-6 and IL-8, were demonstrated to be up-regulated in the LPS-CM, which we supposed to function in the tumor-growth promotion in vitro.

Keywords:

Inflammatory cytokine, LPS, MSC, tumor growth.

Affiliation:

Department of Hematology and Oncology, The First Affiliated Hospital of General Hospital of Chinese People’s Liberation Army (PLA), No. 52,Fucheng Road, Haidian District, Beijing 100039, China.



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