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Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective

[ Vol. 13 , Issue. 8 ]


Alessia Ruggiero, Paola De Simone, Giovanni Smaldone, Flavia Squeglia and Rita Berisio   Pages 756 - 766 ( 11 )


Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.


Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION


Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone, 16. I-80134, Napoli, Italy.

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