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Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective

[ Vol. 13 , Issue. 8 ]

Author(s):

Alessia Ruggiero, Paola De Simone, Giovanni Smaldone, Flavia Squeglia and Rita Berisio   Pages 756 - 766 ( 11 )

Abstract:


Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.

Keywords:

Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION

Affiliation:

Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone, 16. I-80134, Napoli, Italy.



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